School of Bio-Medical Sciences (Bio-Medical)
Recent Submissions
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In silico characterization of peptides for major surface protein 2, rhoptry-associated protein 1, and the vitellogenin receptor as potential vaccine candidates against babesiosis and anaplasmosis
(Makerere University, 2024)Background: Bovine babesiosis and anaplasmosis caused by Babesia bovis and Anaplasma marginale respectively pose significant threats to the livestock industry, particularly in regions where both parasites co-exist. Current ... -
Machine learning and orthology-based design of synergistic drug combinations against aspergillus fumigatus
(Makerere University, 2024)Background: Aspergillus fumigatus is a common fungal species that can cause invasive aspergillosis, particularly in immunocompromised individuals. In Uganda, around 9% of the population suffers from fungal diseases. Drug ... -
Periodontal disease in patients with diabetes mellitus attending Kiruddu National referral Hospital: Prevalence, risk factors, association with glycemic control and insulin resistance
(Makerere University, 2024-12-23)Background: Diabetes mellitus and periodontal disease establish a relationship where one if poorly managed complicates the management of the other. This study set out to describe the association between periodontal diseases ... -
The predictive utility of polygenic risk scores for chronic kidney disease in Africans
(Makerere University, 2024)Background: Genome-wide association studies (GWAS) have significantly expanded our understanding of the genetic basis of kidney function, with most findings reported in individuals of European ancestry. Such biased sampling ... -
Neutralization and antibody-dependent cellular cytotoxicity functions of SARS-CoV-2 Spike-IgG in vaccinated individuals
(Makerere University, 2024)Background: Following the world-wide spread of the SARS-CoV-2 virus during the COVID-19 pandemic, several types of vaccines were rolled out in various countries including Uganda. Studies elsewhere revealed significant ... -
Cytokine profiles of HIV-associated COPD in a Ugandan Cohort
(Makerere University, 2024-11-18)Introduction:COPD is a chronic lung condition characterized by irreversible airflow obstruction and encompasses chronic bronchiolitis and emphysema. Cigarette smoking is the predisposing factor in over 50% of cases but ... -
Development of an antigen agglutination test for rapid screening of COVID-19 in low laboratory capacity and field settings
(MAKERERE UNIVERSITY, 2024-11-29)The transition of COVID-19 from a pandemic to a general disease has highlighted the need for affordable and accessible diagnostic tests to control the spread of SARS-CoV-2. While PCR tests have been the gold standard for ... -
Whole-Genome Sequencing-based characterization of staphylococcus aureus in hospital settings within East Africa
(Makerere University, 2024-12-06)Background: Staphylococus aureus, a Gram-positive facultative anaerobic bacterium, is a prominent pathogen responsible for a wide range of infections, from minor skin conditions to severe, life- threatening diseases. ... -
Performance evaluation of Sanity 2.0 system in detecting high risk Human papillomavirus in Uganda
(Makerere University, 2024)Aim: We aimed to evaluate the performance of the Sanity 2.0 system as a point-of-care screening test for high-risk Human papillomavirus (hr-HPV) using Cobas 4800 as the gold standard. Background: Cervical cancer is a ... -
Bacteremia in hematologic cancer patients with febrile neutropenia in Uganda
(Makerere University, 2024)Background There were 19.3 million new cancer cases and 10 million cancer deaths which occurred in 2020. Compared to high-income countries cancer is a growing public health problem in sub-Saharan Africa, where mortality ... -
Evaluation of the Liofilchem rapid ESBL NP test for the detection of extended spectrum beta-lactamases in Enterobacteriacea in complicated urinary tract infections at Mulago Hospital using direct urine samples
(Makerere University, 2024)Introduction: There is a growing burden of UTIs complicated by drug resistant microorganisms. Antimicrobial resistance (AMR) is a growing global public health threat, with extended- spectrum beta-lactamase (ESBL) producing ... -
Model-based prediction of Dolutegravir dose requirement for HIV exposed neonates in Uganda
(Makerere University, 2024)Introduction: Mother-to-child transmission of HIV is the primary source of HIV infections in children, especially in low-income countries accounting for 14% of all new infections in Uganda. It is recommended that HIV-exposed ... -
Microbial environmental contamination and infection prevention and control practices in the maternity ward of Buwenge General Hospital
(Makerere University, 2024)A 2017 review found that 42.6% of African countries lacked adequate antimicrobial resistance data, with widespread resistance among clinical isolates. In Uganda, despite IPC guidelines, healthcare workers often lack ... -
Evaluation of anticonvulsant activity of the aqueous and total crude extracts of Vernonia amygdalina Delile in pentylenetetrazole-induced seizures in wistar albino rats
(Makerere University, 2024-11-07)Introduction: Seizures due to abnormal electrical activity in the brain leading to convulsions and hence epilepsy have continued to be a serious problem among the population globally including in Uganda. Medicinal plants ... -
Microbiome-induced immune resistance to mycobacterium tuberculosis at the Airway Mucosa
(Makerere University, 2024)Rationale: Mycobacterium tuberculosis (M.tb) remains one of the deadliest infectious pathogens globally. Amidst efforts to control the disease, challenges such as long treatment duration, drug toxicity, and resistance ... -
A comparison of Ubiquitin E3 ligases as surrogate markers for T cell Anergy in active TB
(2024-10-24)Background: Globally, there is an estimated 1.2 million TB-related deaths among HIV-negative people with active TB. Previous studies using ex-vivo and animal models indicate that CD4+ T cell unresponsiveness to Mtb, which ... -
Health profession students' awareness and perspectives on patients' rights
(Makerere University, 2024)Introduction: The concept of human rights in patient care refers to the theoretical and practical application of general human rights. It is universally acknowledged that all human beings possess individual and social ... -
Deciphering Rifampicin resistance among Tuberculosis patients who have trace and indeterminate results on Xpert MTB/RIF ultra assay
(Makerere University, 2024-10-22)Although WHO endorsed the GeneXpert test as the first initial test for Tuberculosis diagnosis, some of the GeneXpert Ultra results include MTB detected trace, RIF resistance indeterminate which necessitates a sample rerun, ... -
Evidence of molecular adaptive evolution of SARS-CoV-2 in Uganda using whole genome sequences
(Makerere University, 2024-10)Background: Seasonal influenza and coronaviruses both exhibit continual adaptive evolution during endemic circulation in the human population. The rapid evolution of human pathogenic RNA viruses can undermine the efforts ... -
Selected bacterial etiology of acute diarrhea in under five children at Mulago National Referral Hospital Kampala, Uganda.
(Makerere University, 2024-10)Background: Diarrhea is understood as the passing of three or more passages of loose or watery stools per day according to WHO and is considered among the major causes of childhood mortality and morbidity. Diarrhea kills ...
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